Business

Target Medicals is a biopharmaceutical company focused on the discovery, development, and commercialization of proprietary scientific achievements in cytochromes P450. Our scope of contract services include recombinant protein expression and purification, assessment of drug and xenobiotics metabolism using drug-metabolizing enzyme system, production of specific purified human cytochrome P450s (including polymorphic forms) and reductases for preclinical studies.

 Contract research:

- Design, expression and purification of cytochrome P450s ready for use in any applications;

- Cytochrome P450-based functional assays (activity in the reconstituted system, products identification) and assay development;

- HTS assay for screening cytochrome P450s ligands;

- Crystallization of cytochromes P450 in complex with ligands;

- Recombinant antibodies development for conformational and linear epitopes of cytochrome P450s

We have in stock available for distribution highly purified recombinant human and pathogenic cytochrome P450s (CYP), their redox partners and modulators (P450-reductase, adrenodoxin reductase, adrenodoxin, cytochrome b5).  List of CYPs will provided upon request.

Our purified cytochromes P450 are also available through Sigma Aldrich Inc. (Part of Merck KGaA)

http://www.sigmaaldrich.com/life-science/biochemicals/biochemical-products.html?TablePage=118899716